Antimicrobial Guidelines

Disclaimer: The recommendations given in this guide are meant to serve as treatment guidelines. They should NOT supplant clinical judgment or Infectious Diseases consultation when indicated. The recommendations were developed for use at Children’s of Alabama and thus may not be appropriate for other settings. We have attempted to verify that all information is correct, but because of ongoing research, practice may change.
Antimicrobial Specific Guidelines
Spectrum of Antimicrobial Treatment (PDF)
As an institution Children’s of Alabama and the Department of Pediatrics has a goal of establishing “criteria for use” for all antimicrobials available to patients. Indication specific orders sets allow for the most appropriate dose to be selected with (WHEN?) the indication or criteria for use is chosen. The order sets guide prescribers on the appropriate use of antibiotics and assure they are prescribed at the right dose.
For a complete list of formulary antimicrobials please visit Children's of Alabama Formweb.
- Renal dosing of Antimicrobials (PDF)
- Standard IV Abx Dosing in the ED (PDF)
- OPAT Laboratory Monitoring Guidelines (PDF)
- Oral Antimicrobials for Common Pediatric Infections (dosing only) (PDF)
Syndrome Specific and Therapeutic Guidelines
Syndrome specific and therapeutic guidelines offer evidence based recommendations for the diagnosis and management of common infectious syndromes encountered in pediatric patients. These pathways promote consistent, high quality care by aligning antimicrobial selection, duration, and supportive management with best available evidence and local epidemiology, while supporting timely de escalation and antimicrobial stewardship principles.
- Clostridioides/Clostridium difficile – Associated Diarrhea (PDF)
- Community Acquired Pneumonia (PDF)
- Complicated Pneumonia Pathway (PDF)
- ED Well-Appearing Febrile Infant Guidelines (PDF)
- Herpes Simplex Virus (less than 42 days of age) (PDF)
- Measles Pathway for ED (PDF)
- Measles Pathway for Inpatients (PDF)
- Outpatient Measles Pathway (non-ED) (PDF)
- Skin and Soft Tissue Infections (PDF)
- Urinary Tract Infections (PDF)










