AYA Clinical Trials and Fertility Preservation
Clinical Trials
You may be eligible to join a clinical trial at Children's of Alabama or University of Alabama at Birmingham (UAB). For more information, please visit the below:
Clinical Trials and Research at Children's of Alabama
Clinical Trials at UAB O’Neal Cancer Center
AYA Clinical Trials and Research
There are also several clinical trials and research studies available to AYA patients with cancer. Please contact AYAProgram@uabmc.edu for additional information.
Unpacking Insurance Coverage for Fertility Preservation (IRB-300013335)
This study evaluates process of insurance coverage for sperm banking (SB), which is recommended for all post-pubertal males newly diagnosed with cancer. Most insurance carriers do not cover sperm banking, but some states have mandates that include limited coverage for sperm banking.
Who is eligible?
- Patients aged 15–24y with male reproductive organs and a new cancer diagnosis
- Planned treatment includes any chemotherapy and/or testicular radiation
- Have insurance (any insurance)
Want to learn more?
Contact: AYAProgram@uabmc.edu
Triptorelin and Protection of Ovarian Reserve in Adolescents and Young Adults with Cancer (ALTE2131 | NCT06513962; IRB-300014507)
This cross-network NCI trial randomizes females at a high risk of premature ovarian insufficiency to receive the GnRH agonist triptorelin, and follows measures of ovarian reserve for 2y after completing cancer therapy.
Who is eligible?
- Females aged <40y newly diagnosed with cancer (excluding breast cancer)
- Must have had first period >6 months prior
- Planned treatment includes an alkylating agent that contribute to CED, e.g., cyclophosphamide, ifosfamide, procarbazine, chlorambucil, BCNU, CCNU, melphalan, thiotepa, busulfan, nitrogen mustard. Dose for <20yo: CED ≥4g/m2 and for ≥20yo any alkylator dose
Want to learn more?
Contact: AYAProgram@uabmc.edu
PRISM-ES (IRB-300010134)
The Promoting Resilience in Stress Management (PRISM) intervention is an age-appropriate program designed to improve mental health in AYAs with cancer through skills-based coaching sessions and a supporting digital app.
Who is eligible?
- Patients of all genders ≥12y and ≤25y at baseline
- Can read and speak English or Spanish
Have completed main cancer-directed therapy [patients receiving oral maintenance chemotherapy (e.g., AYAs with ALL) also eligible].
Want to learn more?
Contact: AYAProgram@uabmc.edu
