Facility
UAB Division of Hematology and Oncology
Children's Title
Director of Developmental Therapeutics
Academic Title
Professor
Credentials
MD
Associated Programs
Neuro-Oncology Program
Gender
Male
Other Titles
Director, Developmental Therapeutics / Scientist, O'Neal Comprehensive Cancer Canter at UAB
County
Jefferson
Secondary Address
1600 7th Ave. S.,
Lowder Bldg., Suite 512
Birmingham, AL 35233
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Office Phone Number
205-638-9285
Fax
205-638-6377
Undergraduate
College of William and Mary
Medical School
Medical College of Georgia
Residency
Pediatric Hematology/Oncology at UAB
Fellowship
University of Alabama-Birmingham
Interests
Pediatric Neuro-Oncology / Pediatric Virotherapy and Immunotherapy Brain Tumor research.
Special Interests
Research Interests: Overarching goal is to improve outcomes for children with malignant brain tumors by developing and improving novel, targeted therapies in the lab and then translating these therapies to clinical trails. Herpes virus (HSV), which typically causes cold sores, has been engineered to be safe for normal cells but can infect and kill cancer sells and stimulate the patient's own immune system to attach the tumor providing a one-two punch at killing tumor cells. To maximize the benefit of this therapy, his lab focuses on determining mechanisms of therapeutic resistance by exploring the role of tumor genotype, phenotype, and microenvironment; and cellular defense mechanisms so that newer viruses, novel combinations, and unique routes of virus delivery may be developed to circumvent resistance mechanisms.

Additional Information: Principal investigator for the first-ever pediatric trial of HSV G207 in children with recurrent or progressive brain cancers (https://clinicaltrials.gov/ct2/show/NCT02457845)
Physician Type
Pediatric Hematologist/Oncologist
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