Pediatric Neuro-Oncology / Pediatric Virotherapy and Immunotherapy Brain Tumor research.
Research Interests: Overarching goal is to improve outcomes for children with malignant brain tumors by developing and improving novel, targeted therapies in the lab and then translating these therapies to clinical trails. Herpes virus (HSV), which typically causes cold sores, has been engineered to be safe for normal cells but can infect and kill cancer sells and stimulate the patient's own immune system to attach the tumor providing a one-two punch at killing tumor cells. To maximize the benefit of this therapy, his lab focuses on determining mechanisms of therapeutic resistance by exploring the role of tumor genotype, phenotype, and microenvironment; and cellular defense mechanisms so that newer viruses, novel combinations, and unique routes of virus delivery may be developed to circumvent resistance mechanisms.
Additional Information: Principal investigator for the first-ever pediatric trial of HSV G207 in children with recurrent or progressive brain cancers (https://clinicaltrials.gov/ct2/show/NCT02457845)